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United States multicenter study of factors predicting the persistence of GH deficiency during the transition period between childhood and adulthood

Charmian A Quigley1*, Anthony J Zagar1, Charlie Chunhua Liu2, David M Brown3, Carol Huseman4, Lynne Levitsky5, David R Repaske6, Eva Tsalikian7 and John J Chipman8

Author Affiliations

1 Lilly Research Laboratories, Indianapolis, IN 46285, USA

2 Allergan, Inc, Irvine, CA, 92612, USA

3 Division of Pediatric Endocrinology, University of Minnesota, Minneapolis, MN, 55455, USA

4 Children’s Mercy Hospital, Kansas City, MO, 64108, USA

5 MassGeneral Hospital for Children, Boston, MA, 02114, USA

6 Nationwide Children’s Hospital, Columbus, OH, 43205, USA

7 University of Iowa, Children’s Hospital of Iowa, Iowa City, IA, 52242, USA

8 Lilly Research Laboratories, Indianapolis, IN, 46285, USA

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International Journal of Pediatric Endocrinology 2013, 2013:6  doi:10.1186/1687-9856-2013-6

Published: 13 February 2013

Abstract

Background

Many patients with childhood-onset growth hormone (GH) deficiency do not fulfill diagnostic criteria for GH deficiency (GHD) after attainment of adult height and may not require long-term GH treatment. Patients with history of idiopathic GHD (IGHD) pose the greatest management dilemma, as data regarding factors predictive of persistent GHD in this group are lacking.

Objectives

The objective of this study was to assess potential predictors of persistent GHD in a US patient cohort during transition from childhood to adulthood, particularly in patients with history of IGHD.

Methods

We studied 73 US patients with history of childhood-onset GHD screened at 21 US pediatric endocrine centers for a randomized clinical trial of GH replacement after attainment of adult height. The cohort comprised 42 boys/men and 31 girls/women aged14–22 years, who had received ≥1 year of GH treatment and had completed linear growth. The main outcome measures were sensitivity, specificity, positive and negative predictive values (PPV, NPV) of clinical and hormonal factors for persistent GHD (defined a priori in this study as peak GH < 5 μg/L).

Results

For the cohort as a whole, the best predictors of persistent GHD (100% PPV) were history of organic hypothalamic-pituitary disorder or ≥2 additional pituitary hormone deficiencies (PHD). Best predictors of persistent GHD in patients with childhood history of IGHD were standard deviation scores (SDS) for serum insulin-like growth factor binding protein-3 (IGFBP-3) below -2.0, and for insulin-like growth factor-I (IGF-I) below -5.3 (measured ≥6 weeks after completion of GH treatment; PPV 100% for both), and age <4 years at original diagnosis (PPV 89%). IGF-I above -1.6 SDS had 100% NPV.

Conclusions

US patients with an organic cause of childhood-onset GHD or ≥2 additional PHDs may not require GH stimulation testing to reconfirm GHD after completion of childhood treatment. In contrast, patients with idiopathic childhood-onset GHD almost invariably require retesting, as GHD persists in only a minority (those who were very young at initial diagnosis and those who have subnormal IGFBP-3 or extremely low IGF-I after completion of childhood treatment). Subnormal posttreatment IGF-I (<-2.0 SDS) lacked predictive power for persistent GHD, whereas IGF-I > -1.6 SDS was 100% predictive of GH sufficiency.

Keywords:
Transition; Growth hormone deficiency; Hypopituitarism; Predictive value of tests; Child; Adolescent; Adult; Idiopathic