Table 1 |
|
| Criteria for diagnosing hyperinsulinism | |
| Clinical Clues | Large for gestational age |
| GIR > 10 mg/kg/min# | |
| Lab findings with glucose < 50 mg/dL | ↓ Beta-hydroxybutyrate (< 0.6 mM) |
| ↓ Free fatty acids (< 0.5 mM) | |
| +/− ↑ Insulin | |
| Glycemic Response to Glucagon* | ↑ Glucose > 30 mg/dL |
* Glucagon stimulation test: When glucose < 50 mg/dL, administer 1 mg glucagon IV/IM and monitor glucose every 10 min for 40 min. If there is no increase in blood glucose by 20 min, terminate test and rescue with IV dextrose. GIR = glucose infusion rate.
# Please note that in some cases the GIR may be lower.
Lord and De León International Journal of Pediatric Endocrinology 2013 2013:3 doi:10.1186/1687-9856-2013-3
